@article { ISI:000332784900001,
	title = {Continuous flow nitration in miniaturized devices},
	journal = {Beilstein Journal of Organic Chemistry},
	volume = {10},
	year = {2014},
	month = {FEB},
	pages = {405-424},
	publisher = {BEILSTEIN-INSTITUT},
	type = {Review},
	address = {TRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANY},
	abstract = {<p>This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic and selectivity sensitive nitration reactions. Four different approaches to flow nitration with microreactors are presented herein and discussed in view of their advantages, limitations and applicability of the information towards scale-up. Selected recent patents that disclose scale-up methodologies for continuous flow nitration are also briefly reviewed.</p>},
	keywords = {continuous flow, flow chemistry, microreactors, nitration, nitric acid, Tubular reactor},
	issn = {1860-5397},
	doi = {10.3762/bjoc.10.38},
	author = {Kulkarni, Amol A.}
}
@article { ISI:000346134300012,
	title = {Continuous-flow meerwein arylation},
	journal = {Journal of Flow Chemistry},
	volume = {4},
	number = {4},
	year = {2014},
	month = {DEC},
	pages = {211-216},
	publisher = {AKADEMIAI KIADO RT},
	type = {Article},
	address = {PRIELLE K U 19, PO BOX 245,, H-1117 BUDAPEST, HUNGARY},
	abstract = {<p>The continuous-flow Meerwein arylation is demonstrated for a set of few aryl donors (anilines and m-aminoacetophenone) and specific radical acceptors. Homogeneous catalyst (CuBr in HBr and CuCl in HCl) was used to facilitate the reaction. The effect of parameters, viz., temperature, catalyst concentration, residence time, and concentration of the radical acceptor on the yield of the arylated product, was studied. The yield of the aryl derivative obtained by continuous-flow syntheses was always better than the respective experiments in batch mode. Flow synthesis allows easy variation in these parameters and thus allows going close to the maximum possible yields in a system where the relative rates of different reactions create a complex situation. Temperature plays a crucial role by affecting the rates as well as by governing the system homogeneity. The nitrogen bubbles generated in the reaction helped to avoid any channel blockage.</p>},
	keywords = {diazonium salt, flow chemistry, homogeneous catalyst, Meerwein arylation, micromixer, multistep synthesis},
	issn = {2062-249X},
	doi = {10.1556/JFC-D-14-00023},
	author = {Bhaya, Vinay G. and Joshi, Ramesh A. and Kulkarni, Amol A.}
}
