@article { ISI:000371304100018,
	title = {Synthesis, biological evaluation and molecular docking of novel coumarin incorporated triazoles as antitubercular, antioxidant and antimicrobial agents},
	journal = {Medicinal Chemistry Research},
	volume = {25},
	number = {4},
	year = {2016},
	month = {APR},
	pages = {790-804},
	publisher = {SPRINGER BIRKHAUSER},
	address = {233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA},
	abstract = {<p>A series of new coumarin-based 1,2,3-triazole derivatives were designed, synthesized and evaluated for their antitubercular activity in vitro against Mycobacterium tuberculosis H37Ra, antioxidant activity by DPPH radical scavenging assay, antimicrobial activity in vitro against three gram-positive bacteria (Staphylococcus aureus, Micrococcus luteus and Bacillus cereus) and three gram-negative bacteria (Escherichia coli, Pseudomonas fluorescens and Flavobacterium devorans as well as three fungi (Aspergillus niger, Penicillium chrysogenum and Curvularia lunata). The bioactive assay showed that some synthesized coumarin triazoles displayed comparable or even better antitubercular, antioxidant, antibacterial and antifungal efficacy in comparison with reference drugs. Furthermore, docking study has been performed against DprE1 enzyme of M. tuberculosis that showed good binding interactions. Moreover, the synthesized compounds were also analyzed for ADME properties and showed potential to build up as good oral drug candidates. New coumarin-based 1,2,3-triazole derivatives were designed, synthesized and evaluated for their antitubercular, antioxidant, antibacterial and antifungal activity. Some of the coumarin-based triazole derivatives displayed comparable or even better efficacy in comparison with reference drugs. Molecular docking study has been performed against DprE1 enzyme of Mycobacterium tuberculosis showed good binding interactions. [GRAPHICS] .</p>},
	keywords = {1, 2, 3-Triazole, ADME prediction, Antimicrobial, Antioxidant, Antitubercular, Click chemistry, Docking study},
	issn = {1054-2523},
	doi = {10.1007/s00044-016-1519-9},
	author = {Shaikh, Mubarak H. and Subhedar, Dnyaneshwar D. and Shingate, Bapurao B. and Khan, Firoz A. Kalam and Sangshetti, Jaiprakash N. and Khedkar, Vijay M. and Nawale, Laxman and Sarkar, Dhiman and Navale, Govinda R. and Shinde, Sandip S.}
}
@article {42943,
	title = {Synthesis of novel triazole-incorporated isatin derivatives as antifungal, antitubercular, and antioxidant agents and molecular docking study},
	journal = {Journal of Heterocyclic Chemistry},
	volume = {54},
	year = {2017},
	month = {JAN},
	type = {Article},
	abstract = {<p>A library of 1,2,3-triazoles efficiently prepared via click chemistry and evaluated for their antifungal, antitubercular, antioxidant, cytotoxicity, molecular docking and ADME prediction.</p>},
	doi = {10.1002/jhet.2598},
	author = {Shaikh, Mubarak H. and Subhedar, Dnyaneshwar D. and Khan, Firoz A. Kalam and Sangshetti, Jaiprakash N. and Nawale, Laxman and Arkile, Manisha A. and Sarkar, Dhiman and Shingate, Bapurao B.}
}
