@article {46610,
	title = {P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent},
	journal = {Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry},
	volume = {59},
	year = {2020},
	month = {DEC},
	pages = {1861-1867},
	type = {Article},
	abstract = {<p>P2O5 has been found to be a highly efficient and environmental friendly catalyst for the liquid-phase acylation of activated aromatic substrates giving aromatic ketones (45-93\%) in a regioselective manner. Both aromatic and aliphatic carboxylic acids can be employed as acylating source. The process is particularly demonstrated at 100 g scale in the case of anisole and acetic acid to produce 4-methoxyacetophenone.</p>
},
	keywords = {4-methoxyacetophenone, Carboxylic acid, Friedel-Crafts acylations, phosphorus pentoxide},
	issn = {0376-4699},
	author = {Kalshetti, Rupali G. and Mandle, Ram D. and Kamble, Sanjay P. and Sudalai, Arumugam}
}
@article {48068,
	title = {Postmodification of voxelotor (GBT 440) via [Rh]-catalyzed cross dehydrogenative coupling with olefins br},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {77},
	year = {2022},
	month = {DEC},
	pages = {129022},
	type = {Article},
	abstract = {<p>
	The directed Rh(III)-catalyzed cross dehydrogenative coupling of the pyrazole unit of the GBT-440 scaffold has been explored with simple as well as conjugated olefins to synthesize post-functionalized GBT-440 analogues. The screening of these synthesized compounds for improving the oxygen binding efficiency of the hemoglobin isolated from the sickled red blood cells revealed that some of these compounds are as good as GBT-440.</p>
},
	keywords = {CDC Coupling, GBT-440 (Voxelotor), Rh(III) catalysis, sickle cell anemia},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2022.129022},
	author = {Kalshetti, Rupali G. and Rajput, Raveena and Motiwala, Zenia and Reddy, D. Srinivasa and Kulkarni, Kiran A. and V. Ramana, Chepuri}
}
