@article {46605,
	title = {HDAC6 ZnF UBP as the modifier of tau structure and function},
	journal = {Biochemistry},
	volume = {59},
	year = {2020},
	month = {DEC },
	pages = {4546-4562},
	type = {Article},
	abstract = {<p>Histone deacetylase 6 is a class H histone deacetylase primarily present in the cytoplasm and involved in the regulation of various cellular functions. It consists of two catalytic deacetylase domains and a unique zinc finger ubiquitin binding protein domain, which sets it apart from other HDACs. HDAC6 is known to regulate cellular activities by modifying the function of microtubules, HSP90, and cortactin through deacetylation. Apart from the catalytic activity of HDAC6, it interacts with other proteins through either the SE14 domain or the ZnF UBP domain to modulate their functions. Here, we have studied the role of the HDAC6 ZnF UBP domain as a modifier of Tau aggregation by its direct interaction with the polyproline region/repeat region of Tau. Interaction of HDAC6 ZnF UBP with Tau was found to reduce the propensity of Tau to self-aggregate and to disaggregate preformed aggregates in a concentration-dependent manner and also bring about the conformational changes in Tau protein. The interaction of HDAC6 ZnF UBP with Tau results in its degradation, suggesting either proteolytic activity of HDAC6 ZnF UBP or its role in enhancing autoproteolysis of Tau.</p>
},
	issn = {0006-2960},
	doi = {10.1021/acs.biochem.0c00585},
	author = {Balmik, Abhishek Ankur and Chidambaram, Hariharakrishnan and Dangi, Abha and Marelli, Udaya Kiran and Chinnathambi, Subashchandrabose}
}
@article {48109,
	title = {Histone deacetylase-6 modulates Tau function in Alzheimer{\textquoteright}s disease},
	journal = {Biochimica Et Biophysica Acta-Molecular Cell Research},
	volume = {1869},
	year = {2022},
	month = {AUG},
	pages = {119275},
	type = {Article},
	abstract = {<p>
	Alzheimer{\textquoteright}s disease (AD), one of the major tauopathies, is multifactorial with a massive demand for disease modifying treatments rather than symptom management. An AD-affected neuron shows Tau depositions generated due to overload on the proteostasis machinery of the cell and/or abnormal post-translational modifications on Tau protein. Loss of memory or dementia is the most significant concern in AD, occurring due to the loss of neurons and the connections between them. In a healthy brain, neurons interact with the environment and each other through extensions and migratory structures. It can thus be safe to assume that Tau depositions affect these growth structures in neurons. A Histone Deacetylase, HDAC6, has shown elevated levels in AD while also demonstrating direct interaction with the Tau protein. HDAC6 interacts with multiple proteins in the cell and is possibly involved in various signalling pathways. Its deacetylase activity has been a point of controversy in AD; however other functional domains remain unexplored. This review highlights the beneficial potential of HDAC6 in AD in mediating both Tau proteostasis and cytoskeletal rewiring for the neuritic extensions through its Ubiquitin Binding domain (HDAC6 ZnF UBP).</p>
},
	keywords = {Actin, Cytoskeleton, HDAC6, Microtubules, Proteostasis, Tau, ZnF UBP domain},
	issn = {0167-4889},
	doi = {10.1016/j.bbamcr.2022.119275},
	author = {Qureshi, Tazeen and Chinnathambi, Subashchandrabose}
}
