@article {49381,
	title = {Unravelling the prebiotic origins of the simplest α-ketoacids in cometary ices: a computational investigation},
	journal = {CHEMICAL COMMUNICATIONS},
	volume = {60},
	year = {2024},
	month = {OCT },
	pages = {11283-11286},
	type = {Journal Article},
	keywords = {GLYOXYLATE, Hydrocarbons, Metabolism, Precursors},
	issn = {1359-7345},
	doi = {10.1039/d4cc03074e},
	author = {Dash, Soumya Ranjan and Pandya, Rinu and Singh, Geetika and Sharma, Himanshu and Das, Tamal and Haldar, Hritwik and Hotha, Srinivas and Vanka, Kumar}
}
@article {49507,
	title = {Studies on the stereoselective synthesis of sacubitril via a chiral amine transfer approach},
	journal = {Chemistry-An Asian Journal},
	volume = {20},
	year = {2025},
	month = {MAR },
	type = {Article},
	abstract = {<p>
	We present a comprehensive account of our efforts directed towards the synthesis of sacubitril, a neprilysin inhibitor used in combination with valsartan and marketed as Entresto (TM). Our initial approach to the formal synthesis of sacubitril employed a chiral pool strategy, utilizing (S)-pyroglutamic acid as a key building block and Cu(I)-mediated Csp2-Csp3 cross-coupling as a key transformation. Further investigations led to the development of chiral amine transfer (CAT) reagents-based stereoselective synthesis. This involved the E-selective construction of gamma-ylidene-butenolide from readily available biphenyl bromide and 4-pentynoic acid, the conversion of this butenolide to its ene-lactam using chiral amine, and substrate-controlled diastereoselective reduction of ene-lactam using Et3SiH or Pd/C, H2 (overall chiral amine transfer) as key transformations. Antipodal lactam intermediates were synthesized using corresponding chiral amines, and the stereochemical outcomes during the ene-lactam reduction with Et3SiH were rationalized by DFT studies.</p>
},
	keywords = {Chiral Amine Transfer (CAT) approach, Chiral pool approach, Sacubitril, stereoselective synthesis},
	issn = {1861-4728},
	doi = {10.1002/asia.202401223},
	author = {Sadanande, Megha V. and Thorat, Sagar S. and Sharma, Himanshu and Singh, Geetika and Vanka, Kumar and Gonnade, Rajesh G. and Kontham, Ravindar}
}
