@article {49257, title = {Biocatalysis enables the scalable conversion of biobased furans into various furfurylamines}, journal = {NATURE COMMUNICATIONS}, volume = {15}, year = {2024}, month = {JUL }, type = {Journal Article}, keywords = {Biomass, OMEGA-TRANSAMINASE, OXIDASE, Reductive amination, SPECIFICITY}, doi = {10.1038/s41467-024-50637-x}, author = {Giri, Pritam and Lim, Seonga and Khobragade, Taresh P. and Pagar, Amol D. and Patil, Mahesh D. and Sarak, Sharad and Jeon, Hyunwoo and Joo, Sangwoo and Goh, Younghwan and Jung, Seohee and Jang, Yu-Jeong and Choi, Seung Beom and Kim, Ye Chan and Kang, Taek Jin and Heo, Yong-Seok and Yun, Hyungdon} } @article {49449, title = {photoarchitectonic hydrogel for synergistic in vitro chemo{\textendash}phototherapy of breast cancer}, journal = {Materials Advances}, volume = {5}, year = {2024}, month = {JAN}, pages = {1903-1916}, type = {Article}, abstract = {

Currently, combinatorial therapy has evoked interest in cancer treatment, and may promote achieving a synergistic effect using cancer medicines. Laser-assisted and pH-responsive therapies have attracted significant attention, and their combination leads to high efficiency cancer treatment. Herein, we developed a chemo{\textendash}phototherapeutic hydrogel comprised of doxorubicin (DOX, a chemotherapeutic drug) and zinc phthalocyanine (ZnPc, a phototherapeutic drug) for combinatorial and synergistic treatment of breast cancer. Firstly, we have developed carbon dots (CDs, size of \~{}5 nm) utilizing lignin and folic acid as biocompatible sources. Then doxorubicin was loaded on the surface of the carbon dots\ via\ conjugation (DOX@CDs). Later on, zinc phthalocyanine and acrylic acid derivatives were utilized to develop a laser-responsive hydrogel (ZnPc-PP H). Afterward, doxorubicin-conjugated carbon dots were incorporated into the photoarchitectonic hydrogel to develop a chemo{\textendash}phototherapeutic drug-loaded hydrogel (DOX@CDs{\textendash}ZnPc-PP H). Subsequently, the\ in vitro\ pH-triggering experiments demonstrated that the hydrogel loaded with both DOX and ZnPc could release the drugs in an acidic environment. Interestingly,\ in vitro\ assays confirmed that DOX@CDs{\textendash}ZnPc-PP H could effectively target breast cancer cells (MCF-7). Furthermore, the developed chemo{\textendash}phototherapeutic hydrogel exhibited non-cytotoxic behavior. Owing to laser assisted reactive oxygen species generation from ZnPc present in the hydrogel, the growth of MCF-7 cells was significantly lowered. In conclusion, all experimental outcomes indicate that the photoarchitectonic hydrogel has the potential to be applied in synergistic chemo- and photodynamic therapy of cancer.

}, doi = {https://doi.org/10.1039/D3MA00900A}, author = {Paul, Shatabdi and Yadav, Binduma and Patil, Mahesh D. and Pujari, Anil Kumar and Singh, Umesh and Rishi, Vikas and Bhaumik, Jayeeta} }