@article { ISI:000234092500005, title = {Convenient synthesis of the enantiomerically pure beta-blocker (S)-betaxolol using hydrolytic kinetic resolution}, journal = {Tetrahedron-Asymmetry}, volume = {16}, number = {23}, year = {2005}, month = {NOV}, pages = {3802-3806}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Enantiopure (S)-betaxolol was prepared in an extremely simple and practical way using hydrolytic kinetic resolution of a terminal epoxide by Jacobsen{\textquoteright}s catalyst. High enantiomeric purity (99\% ee) has been achieved and the method is amenable to industrial scale-up. (c) 2005 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2005.10.028}, author = {Joshi, Ramesh A. and Garud, Dinesh R. and Muthukrishnan, Murugan and Joshi, Rohini R. and Gurjar, M. K.} } @article { ISI:000229476800007, title = {Facile oxidation of flavanones to flavones using [hydroxy(tosyloxy)iodo]benzene in an ionic liquid}, journal = {Mendeleev Communications}, volume = {15}, number = {3}, year = {2005}, month = {MAY}, pages = {100-101}, publisher = {ELSEVIER SCIENCE BV}, type = {Article}, address = {PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS}, abstract = {

A method for the oxidation of flavationes to flavones has been developed using [hydroxy(tosyloxy)iodo] benzene (HTIB) in the room-temperature ionic liquid 1,3-di-n-butylimidazolium bromide ([bbim]Br-+(-)).

}, issn = {0959-9436}, doi = {10.1070/MC2005v015n03ABEH001997}, author = {Muthukrishnan, Murugan and Patil, P. S. and More, Shivaji V. and Joshi, Ramesh A.} } @article { ISI:000238072500037, title = {Pictet-Spengler cyclization in room temperature ionic liquid: a convenient access to tetrahydro beta-carbolines}, journal = {Journal of Heterocyclic Chemistry}, volume = {43}, number = {3}, year = {2006}, month = {MAY}, pages = {767-772}, publisher = {HETERO CORPORATION}, type = {Article}, address = {PO BOX 170, PROVO, UT 84603-0170 USA}, abstract = {

1,2,3,4-Tetrahydro-beta-carbolines have been synthesized in moderate to good yields in short reaction time using the ionic liquid [bbim] BF4 as reaction medium and promoter. There was no need for the use of an additional catalyst normally employed in Pictet-Spengler condensation.

}, issn = {0022-152X}, author = {Muthukrishnan, Murugan and More, Shivaji V. and Garud, Dinesh R. and Ramana, C. V. and Joshi, Rohini R. and Joshi, Ramesh A.} } @article { ISI:000244054900016, title = {Concise synthesis of beta-blockers (S)-metoprolol and (S)-betaxolol using hydrolytic kinetic resolution}, journal = {Tetrahedron}, volume = {63}, number = {8}, year = {2007}, month = {FEB}, pages = {1872-1876}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Enantiopure (S)-metoprolol and (S)-betaxolol were prepared in an extremely simple and practical way using Jacobsen{\textquoteright}s hydrolytic kinetic resolution of terminal epoxides in isopropanol. (c) 2007 Elsevier Ltd. All rights reserved.

}, keywords = {beta-blockers, betaxolol, Hydrolytic kinetic resolution, metoprolol}, issn = {0040-4020}, doi = {10.1016/j.tet.2006.12.016}, author = {Muthukrishnan, Murugan and Garud, Dinesh R. and Joshi, Rohini R. and Joshi, Ramesh A.} } @article { ISI:000260210000002, title = {Thallium(III) p-tosylate mediated oxidative 2,3-aryl rearrangement: a new useful route to ipriflavone and its analogs}, journal = {Synthetic Communications}, volume = {38}, number = {22}, year = {2008}, month = {MAR}, pages = {3875-3883}, publisher = {TAYLOR \& FRANCIS INC}, type = {Article}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

A new route for the synthesis of ipriflavone, an antiosteoporotic agent, is described that has four steps and 60\% yields starting from resacetophenone (2). The key step of the present methodology is thallium(III) p-tosylate mediated oxidative 2,3-aryl rearrangement of flavanone to generate the isoflavone ring system of ipriflavone in a highly efficient manner.

}, keywords = {Flavanones, ipriflavone, isoflavones, oxidative rearrangement, thallium(III) p-tosylate}, issn = {0039-7911}, doi = {10.1080/00397910802238734}, author = {Muthukrishnan, Murugan and Singh, Om V.} } @article { ISI:000274985000008, title = {Convenient synthesis of enantiomerically pure (R)-mexiletine using hydrolytic kinetic resolution method}, journal = {Tetrahedron-Asymmetry}, volume = {20}, number = {24}, year = {2009}, month = {DEC}, pages = {2814-2817}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

Enantiopure (R)-mexiletine was prepared in a simple and practical way using hydrolytic kinetic resolution method of terminal epoxide by Jacobsen catalyst. High enantiomeric purity (98\% ee) was achieved and the method is well amenable to industrial scale-up. (C) 2009 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2009.11.014}, author = {Sasikumar, Murugesan and Nikalje, Milind D. and Muthukrishnan, Murugan} } @article { ISI:000265958900008, title = {First ionic liquid-promoted Kabbe condensation reaction for an expeditious synthesis of privileged bis-spirochromanone scaffolds}, journal = {Tetrahedron Letters}, volume = {50}, number = {22}, year = {2009}, month = {JUN}, pages = {2643-2648}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A variety of privileged bis-spirochromanones were synthesized for the First time from 4,6-diacetyl resorcinol in one-pot by carrying out the Kabbe condensation in loom temperature ionic liquid [bbim]Br. (C) 2009 Elsevier Ltd. All rights reserved.

}, keywords = {Bis-spirochromanone, Ionic liquid, Kabbe condensation, Morpholine}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2009.03.104}, author = {Muthukrishnan, Murugan and Basavanag, U. M. V. and Puranik, Vedavati G.} } @article { ISI:000286862600011, title = {Facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method}, journal = {Tetrahedron-Asymmetry}, volume = {21}, number = {23}, year = {2010}, month = {DEC}, pages = {2825-2829}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A practical and highly efficient enantioselective synthesis of (R)-phenoxybenzamine hydrochloride has been described for the first time using Jacobsen{\textquoteright}s hydrolytic kinetic resolution of a terminal epoxide as a key step and source of chirality. (C) 2010 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2010.11.011}, author = {Nikalje, Milind D. and Sasikumar, Murugesan and Muthukrishnan, Murugan} } @article { ISI:000277738400017, title = {Simple and efficient synthesis of 2-Aryl-2,3-dihydroquinolin-4(1H)-ones using silica chloride as a new catalyst under solvent-free conditions}, journal = {Synthetic Communications}, volume = {40}, number = {9}, year = {2010}, month = {APR}, pages = {PII 921000023}, publisher = {TAYLOR \& FRANCIS INC}, address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA}, abstract = {

A mild, efficient, and high-yielding method for the synthesis of 2-aryl-2,3-dihydroquinolin-4(1H)-ones from their corresponding 2-amino chalcones using silica chloride (SiO2Cl) under solvent-free conditions is described. A series of 2-aryl-2,3-dihydroquinolin-4(1H)-ones containing both electron-donating and electron-withdrawing substituents were synthesized.

}, keywords = {2-Amino chalcones, 2-aryl-2, 3-dihydroquinolin-4(1H)-ones, Microwave, silica chloride}, issn = {0039-7911}, doi = {10.1080/00397910903097252}, author = {Muthukrishnan, Murugan and Mujahid, Mohammad and Punitharasu, V. and Dnyaneshwar, D. A.} } @article { ISI:000295444000015, title = {First asymmetric synthesis of the antiepileptic drug lacosamide (Vimpat (R)) based on a hydrolytic kinetic resolution strategy}, journal = {Tetrahedron-Asymmetry}, volume = {22}, number = {12}, year = {2011}, month = {JUN}, pages = {1353-1357}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An efficient asymmetric synthesis of the new antiepileptic drug, Lacosamide is described in high enantiopurity (\>98\% ee), using Jacobsen{\textquoteright}s hydrolytic kinetic resolution strategy as a key step. (C) 2011 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2011.07.024}, author = {Muthukrishnan, Murugan and Mujahid, Mohammad and Sasikumar, M. and Mujumdar, P.} } @article { ISI:000290075500029, title = {Syntheses and biological evaluation of new triazole-spirochromone conjugates as inhibitors of mycobacterium tuberculosis}, journal = {Tetrahedron Letters}, volume = {52}, number = {18}, year = {2011}, month = {MAY}, pages = {2387-2389}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A series of novel 1,2,3-triazole fused spirochromone conjugates have been synthesized bearing both spirochromone moiety as well as a 1,2,3-triazole moiety. Some of the compounds have exhibited potential activity against Mycobacterium tuberculosis (virulent strain H37Rv). In particular 5e proved to be the most potent derivative exhibiting MIC = 0.78 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.

}, keywords = {Antitubercular activity, Click chemistry, Mycobacterium tuberculosis, Spirochromones}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2011.02.099}, author = {Muthukrishnan, Murugan and Mujahid, Mohammad and Yogeeswari, P. and Sriram, D.} } @article { ISI:000311473600008, title = {Alternate synthesis of enantiomerically pure levetiracetam (Keppra (R))}, journal = {Tetrahedron-Asymmetry}, volume = {23}, number = {20-21}, year = {2012}, month = {NOV}, pages = {1512-1515}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A simple and efficient synthesis of levetiracetam has been achieved with high enantiopurity (\>99\%) starting from commercially available benzyl glycidyl ether. The method is amenable for industrial scale-up. (C) 2012 Elsevier Ltd. All rights reserved.

}, issn = {0957-4166}, doi = {10.1016/j.tetasy.2012.10.006}, author = {Mujahid, Mohammad and Mujumdar, P. and Sasikumar, M. and Kunte, S. S. and Muthukrishnan, Murugan} } @article { ISI:000327312400019, title = {New enantioselective synthesis of the anticonvulsant drug pregabalin (lyrica) based on a hydrolytic kinetic resolution method}, journal = {Chirality}, volume = {25}, number = {12}, year = {2013}, month = {DEC}, pages = {965-969}, publisher = {WILEY-BLACKWELL}, address = {111 RIVER ST, HOBOKEN 07030-5774, NJ USA}, abstract = {

A practical and efficient enantioselective synthesis of the anticonvulsant drug pregabalin is described for the first time using Jacobsen{\textquoteright}s hydrolytic kinetic resolution of a terminal epoxide as a key step and a source of chirality. Chirality 25:965-969, 2013. (c) 2013 Wiley Periodicals, Inc.

}, keywords = {anticonvulsant drug, Hydrolytic kinetic resolution, pregabalin}, issn = {0899-0042}, doi = {10.1002/chir.22253}, author = {Mujahid, Mohammad and Muthukrishnan, Murugan} } @article { ISI:000314693400052, title = {Synthesis and antitubercular activity of amino alcohol fused spirochromone conjugates}, journal = {Bioorganic \& Medicinal Chemistry Letters}, volume = {23}, number = {5}, year = {2013}, month = {MAR}, pages = {1416-1419}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A series of 21 new amino alcohol fused spirochromone conjugates have been synthesized, characterized with analytical data and evaluated their antimycobacterial activity against Mycobacterium tuberculosis (virulent strain H37Rv) in vitro. Some of the compounds exerted significant inhibition, in particular, compound 4f found to be the most potent derivative exhibiting MIC = 3.13 mu g/mL. (C) 2013 Elsevier Ltd. All rights reserved.

}, keywords = {Amino alcohol, Antitubercular activity, Mycobacterium tuberculosis, Spirochromones}, issn = {0960-894X}, doi = {10.1016/j.bmcl.2012.12.073}, author = {Mujahid, Mohammad and Gonnade, Rajesh G. and Yogeeswari, P. and Sriram, D. and Muthukrishnan, Murugan} } @article { ISI:000336700700003, title = {New enantioselective synthesis of (S)-2-ethoxy-3-(4-hydroxyphenyl)Propanoic acid esters (EEHP and IEHP), useful pharmaceutical intermediates of PPAR agonists}, journal = {Tetrahedron Letters}, volume = {55}, number = {21}, year = {2014}, month = {MAY}, pages = {3223-3226}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, type = {Article}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A new enantioselective synthetic route to the title compounds has been developed in a simple and practical way with high enantiopurity using commercially available starting material. (C) 2014 Elsevier Ltd. All rights reserved.

}, keywords = {EEHP, Epoxide, IEHP, PPAR agonists}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2014.04.021}, author = {Mujahid, Mohammad and Kunte, S. S. and Muthukrishnan, Murugan} } @article { ISI:000338109600007, title = {New enantioselective synthesis of the anti-parkinson agent safinamide}, journal = {Synthesis-Stuttgart}, volume = {46}, number = {13}, year = {2014}, month = {JUL}, pages = {1751-1756}, publisher = {GEORG THIEME VERLAG KG}, type = {Article}, address = {RUDIGERSTR 14, D-70469 STUTTGART, GERMANY}, abstract = {

An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues

}, keywords = {Amides, medicinal chemistry, safinamide, stereoselective synthesis}, issn = {0039-7881}, doi = {10.1055/s-0033-1341104}, author = {Reddi, Anjaneyulu and Mujahid, Mohammad and Sasikumar, Murugesan and Muthukrishnan, Murugan} } @article { ISI:000360510700002, title = {Chiral aziridine ring opening: facile synthesis of (R)-modletine and (R)-phenoxybenzamine hydrochloride}, journal = {Tetrahedron Letters}, volume = {56}, number = {38}, year = {2015}, month = {SEP}, pages = {5269-5271}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

A simple and efficient synthesis of chiral drugs (R)-mexiletine 1, an anti-arrhythmic drug and (R)-phenoxybenzamine hydrochloride 2, an anti-hypertensive drug has been described via controlled reductive ring opening of chiral aziridine as a key step. The target compounds 1 and 2 were obtained in overall yields of 34\% and 10.5\%, respectively. (C) 2015 Elsevier Ltd. All rights reserved.

}, keywords = {Aziridine, Mexiletine, Phenoxybenzamine}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2015.07.032}, author = {Viswanadh, N. and Velayudham, R. and Jambu, S. and Sasikumar, M. and Muthukrishnan, Murugan} } @article { ISI:000360934800002, title = {Pharmacophore and docking based virtual screening of validated mycobacterium tuberculosis targets}, journal = {Combinatorial Chemistry \& High Throughput Screening}, volume = {18}, number = {7}, year = {2015}, month = {AUG}, pages = {624-637}, publisher = {BENTHAM SCIENCE PUBL LTD}, address = {EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATES}, abstract = {

Target based virtual screening has surpassed ligand based virtual screening methods in the recent past mainly as it provides more clues regarding intermolecular interactions and takes into consideration the flexible receptor as well. The current methodology describes a computational strategy of predicting Mycobacterium tuberculosis (M. tuberculosis) binders for five well studied targets representing M. tuberculosis proteome encompassing most of the known mechanisms of action. The diversity of the targets was affirmed by their active site analysis and structural studies. The current approach employed pharmacophore searching, docking and clustering techniques in tandem and was validated by enrichment studies using the available Schrodinger data set consisting of 1000 decoys. The application of this methodology was demonstrated by predicting potential molecular targets for fifty newly synthesized compounds. Cross docking studies on the targets were carried out with 4512 known inhibitors utilizing a high performance computing platform to reveal underlying affinity and promiscuity patterns. Optimum binding energy range for all targets as determined by high throughput docking was found to be -3 to -13 kcal/mol.

}, keywords = {Binding energy, docking, Mycobacterium tuberculosis, open source drug discovery (OSDD), pharmacophore, structure based drug design (SBDD)}, issn = {1386-2073}, doi = {10.2174/1386207318666150703112759}, author = {Vyas, Renu and Karthikeyan, Muthukumarasamy and Nainaru, Ganesh and Muthukrishnan, Murugan} } @article { ISI:000370307800008, title = {Alternate synthesis of appetite suppressant (R)-2-benzylmorpholine employing Sharpless asymmetric epoxidation strategy}, journal = {Tetrahedron Letters}, volume = {57}, number = {8}, year = {2016}, month = {FEB}, pages = {861-863}, publisher = {PERGAMON-ELSEVIER SCIENCE LTD}, address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND}, abstract = {

An alternate synthesis of (R)-2-benzylmorpholine 1, an appetite suppressant agent has been accomplished starting from readily available trans-cinnamyl alcohol employing Sharpless asymmetric epoxidation strategy as a key step, with an overall yield of 24\%. (C) 2016 Elsevier Ltd. All rights reserved.

}, keywords = {(R)-2-Benzylmorpholine, Appetite suppressant, Sharpless asymmetric epoxidation}, issn = {0040-4039}, doi = {10.1016/j.tetlet.2016.01.032}, author = {Viswanadh, N. and Mujumdar, P. and Sasikumar, M. and Kunte, S. S. and Muthukrishnan, Murugan} } @article {43843, title = {Efficient synthesis of the opioid analgesic (R)-phenampromide via an aziridinium ion}, journal = {Tetrahedron-Asymmetry}, volume = {28}, year = {2017}, month = {JUL}, pages = {983-986}, type = {Article}, abstract = {A simple and efficient synthesis of the opioid analgesic agent (R)-phenampromide with high enantiopurity (> 99\% ee) via the formation of an aziridinium ion as a key step using commercially available starting material is described. (C) 2017 Elsevier Ltd. All rights reserved.}, doi = {10.1016/j.tetasy.2017.06.001}, author = {Mujahid, Mohammad and Mujumdar, Prashant and Sasikumar, Murugesan and Deshmukh, Shirish P. and Muthukrishnan, Murugan} } @article {43499, title = {New and efficient enantioselective synthesis of both enantiomers of the calcium channel blocker bepridil}, journal = {New Journal of Chemistry}, volume = {41}, year = {2017}, month = {JAN}, pages = {824-829}, abstract = {A concise and efficient enantioselective synthesis of both enantiomers of bepridil, a calcium channel blocker, is reported. Jacobsen{\textquoteright}s hydrolytic kinetic resolution method was utilized to resolve racemic 2-(isobutoxymethyl) oxirane. The incorporation of the succinimide moiety by the Mitsunobu reaction, which was investigated in detail, occurred without any loss of enantioselectivity. Using this strategy, both enantiomers of the target molecule were obtained in good yield and with high enantiopurity (ee > 99\%).}, doi = {10.1039/c6nj02928k}, author = {Mujahid, Mohammad and Subramanian, Jambu and Nalla, Viswanadh and Sasikumar, Murugesan and Kunte, Sunita Sharad and Muthukrishnan, Murugan} } @article {47675, title = {Thallium(III) p-tosylate-mediated oxidative [1,2] rearrangement of 2-naphthyl and 2-heteroarylchromanones}, journal = {Journal of Heterocyclic Chemistry}, volume = {59}, year = {2022}, month = {JAN}, pages = {172-177}, type = {Article}, abstract = {A practical and effective approach towards the synthesis of 3-heteroaryl-4H-chromen-4-ones by the oxidative [1,2] rearrangement of the respective 2-heteroaryl chroman-4-ones using thallium(III) p-tosylate is presented. The oxidative rearrangement of alpha- and beta-naphthyl and thiophene substituents behaves like aryl groups; However, pyridyl substituents gave only dehydrogenated products.}, issn = {0022-152X}, doi = {10.1002/jhet.4377}, author = {Kurapati, Chidvilas and Muthukrishnan, Murugan and Singh, V. Om and Gundla, Rambabu} }