@article {46323,
	title = {Nickel-catalyzed C(2)-H arylation of indoles with aryl chlorides under neat conditions},
	journal = {Journal of Organic Chemistry},
	volume = {84},
	year = {2019},
	month = {OCT},
	pages = {12800-12808},
	type = {Article},
	abstract = {<p>Nickel-catalyzed regioselective C(2)-H arylation of indoles and pyrroles with aryl chlorides is achieved under neat conditions. This method allows the efficient coupling of diverse aryl chlorides employing a user-friendly and inexpensive Ni(OAc)(2)/dppf catalyst system at 80 degrees C. Numerous functionalities, such as halides, alkyl ether, fluoro-alkyl ether, and thioether, and substituted amines, including heteroarenes like benzothiazolyl, pyrrolyl, indolyl, and carbazolyl, are well tolerated under the reaction conditions. The preliminary mechanistic study highlights a single-electron transfer (SET) pathway for the arylation reaction.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.9b01375},
	author = {Pandey, Dilip K. and Vijaykumar, Muniyappa and Punji, Benudhar}
}
@article {46311,
	title = {Nickel-catalyzed C-H alkylation of indoles with unactivated alkyl chlorides: evidence of a Ni(i)/Ni(iii) pathway},
	journal = {Chemical Science},
	volume = {10},
	year = {2019},
	month = {NOV},
	pages = {9493-9500},
	type = {Article},
	abstract = {<p>A mild and efficient nickel-catalyzed method for the coupling of unactivated primary and secondary alkyl chlorides with the C-H bond of indoles and pyrroles is described which demonstrates a high level of chemo and regioselectivity. The reaction tolerates numerous functionalities, such as halide, alkenyl, alkynyl, ether, thioether, furanyl, pyrrolyl, indolyl and carbazolyl groups including acyclic and cyclic alkyls under the reaction conditions. Mechanistic investigation highlights that the alkylation proceeds through a single-electron transfer (SET) process with Ni(i)-species being the active catalyst. Overall, the alkylation follows a Ni(i)/Ni(iii) pathway involving the rate-influencing two-step single-electron oxidative addition of alkyl chlorides.</p>
},
	issn = {2041-6520},
	doi = {10.1039/c9sc01446b},
	author = {Pandey, Dilip K. and Ankade, Shidheshwar B. and Ali, Abad and Vinod, C. P. and Punji, Benudhar}
}
