@article {48039, title = {Poly(N-vinylcaprolactam) containing solid lipid polymer hybrid nanoparticles for controlled delivery of a hydrophilic drug gemcitabine hydrochloride}, journal = {RSC Advances}, volume = {12}, year = {2022}, month = {JUN}, pages = {17621-17628}, type = {Article}, abstract = {

Folic acid tagged and hydrophilic polymer containing solid lipid nanoparticles (SLNs) were formulated for the controlled and targeted delivery of gemcitabine, a hydrophilic drug. Drug loaded SLNs were prepared by double emulsion method and optimized by 3(2) level factorial design. Then, a hydrophilic polymer, namely, poly(N-vinylcaprolactam) (PVCL) was incorporated in the optimized SLN batch in the first aqueous phase (W1) to obtain solid lipid polymer hybrid nanoparticles (SLPHNs) that were further decorated with folic acid (F-SLPHNs). TEM analysis of SLNs and SLPHNs revealed the spherical shape with no aggregation while SLPHNs showed higher \% EE. SLPHNs exhibited limited burst release of gemcitabine compared to SLNs as well as lower overall \% release. All the formulations showed good cytocompatibility against MDA-MB-231 cell lines and folic acid-tagged hybrid particles (F-SLPHNs) showed remarkably higher cellular uptake.

}, doi = {10.1039/d2ra02845j}, author = {Surapaneni, Sai Geetika and Ambade, V. Ashootosh} } @article {49311, title = {Photo and pH dual stimuli-responsive block copolymer micelles with defined incorporation of o-nitrobenzyl units in poly(ε-caprolactone) ε-caprolactone) block for controlled release}, journal = {European Polymer Journal}, volume = {220}, year = {2024}, month = {NOV}, pages = {113501}, type = {Article}, abstract = {

A series of dual stimuli-responsive block copolymers with varying content of photocleavable o-nitrobenzyl (ONB) ester group pendent in the hydrophobic poly(epsilon-caprolactone) block and pH-cleavable acetal linkage at the junction with hydrophilic poly(ethylene glycol) block is synthesized. The hydrophobic block is a random copolymer synthesized by ring-opening copolymerization of epsilon-caprolactone and ONB-substituted epsilon-caprolactone containing varying compositions of the two monomers. Kinetics of polymerization shows that ONBfunctionalized monomer has lower reactivity than that of the unsubstituted monomer. The series of block copolymers shows self-assembly into well-defined spherical micelles of average size of 150-200 nm in aqueous solution. Photocleavage of ONB groups is studied by NMR and UV-vis spectroscopy, and its extent is determined. The two stimuli viz. . UV light and pH are used individually as well as simultaneously to study the controlled release of the encapsulated drug Camptothecin and the synergistic effect of the two stimuli is demonstrated. The effect of varying content of ONB groups is observed on drug release profile. MTT assay showed non-cytotoxic nature of the polymer. Cell uptake and photoinduced release of doxorubicin (DOX) from the micelles in MDAMB-231 cells is demonstrated.

}, keywords = {drug delivery, micelles, O-nitrobenzyl, pH-responsive, Photoresponsive, Poly(epsilon-caprolactone)}, issn = {0014-3057}, doi = {10.1016/j.eurpolymj.2024.113501}, author = {Avhad, V. Shankarrao and Choudhari, Shakeb N. and Ambade, V. Ashootosh} } @article {49618, title = {Methoxyl-containing hyper-crosslinked polymer from largely bio-based biphenyl methyl ether and its application in lithium-sulfur battery}, journal = {Reactive \& Functional Polymers}, volume = {207}, year = {2025}, month = {FEB}, pages = {106139}, type = {Article}, abstract = {

A new biphenyl methyl ether viz 2,2 {\textquoteleft},3,3 {\textquoteleft}-tetramethoxy-5,5 {\textquoteleft}-bis(methoxymethyl)-1,1 {\textquoteleft}-biphenyl (TBMB) was synthesized starting from vanillin via three-step reaction sequence. The self-polycondensation of TBMB by employing two Bronsted acid catalysts, viz, p- toluenesulfonic acid (PTSA) and trifluoromethanesulfonic acid (TFSA) led to the formation of organic hyper-crosslinked polymers (HCPs) containing built-in methoxyl groups. HCPs were characterized by FTIR, solid state 13 C NMR, XPS, XRD, TGA, BET, and FESEM analysis techniques. HCPs synthesized using PTSA (HCP-PTSA) and TFSA (HCP-TFSA) exhibited a Brunauer-Emmett-Teller (BET) surface area of 480 +/- 5 and 590 +/- 4 m2/g, respectively and consisted of hierarchical pore structures with both micropores and mesopores. HCP-TFSA was evaluated as an active coating layer on conventional polypropylene (PP) separator in lithium-sulfur batteries to suppress the polysulfide shuttling on account of the ability of methoxyl groups to anchor soluble polysulfide species via coordination. The significant polysulfide adsorption capacity and improved cycling stability with a capacity of 617.2 mAh g- 1 at 0.5C and 99\% capacity retention highlighted the potential of porous HCP containing built-in methoxyl groups in the development of attractive lithium-sulfur battery systems.

}, keywords = {Active coating layer, bio-based, Biphenyl methyl ether, Hyper-crosslinked polymer, lithium-sulfur battery, Methoxyl groups, Self-polycondensation}, issn = {1381-5148}, doi = {10.1016/j.reactfunctpolym.2024.106139}, author = {Wale, Apparav K. and Das, Anoushka K. and Patil, Nita R. and Shelke, V. Manjusha and Ambade, V. Ashootosh and Wadgaonkar, Prakash P.} }