@article {47676,
	title = {Ni-catalyzed highly enantioselective synthesis of sulfur protected P-stereogenic supramolecular phosphine},
	journal = {Journal of Chemical Sciences},
	volume = {133},
	year = {2021},
	month = {DEC},
	pages = {119},
	type = {Article},
	abstract = {As phosphines readily invert, the synthesis of P-chiral phosphines is a challenging task and has been rarely investigated. We report the synthesis of a nickel complex [Ni-((S,S)Me-FerroLANE)(phenyl)(I)] (Ni-Cat.1) and its performance in a P-C coupling reaction to generate P-chiral phosphine. The Ni-Cat.1 was synthesized by mixing ligand (S,S) Me-FerroLANE with the metal precursor [(diphenylphosphanyl)nickel(phenyl)(I)] in good yield. Ni-Cat.1 was characterized using different spectroscopic and analytical techniques. Treatment of racemic methyl(phenyl)phosphine (1) with 1-(3-iodophenyl)urea (2) produced the corresponding P-chiral supramolecular phosphine (3). Optimization of reaction parameters produced sulfur protected phosphine N-(3-(methyl(phenyl)phosphorothioyl)phenyl)formamide (3{\textquoteright}) with excellent enantiomeric excess (99\% ee) and moderate conversion (51\%).},
	keywords = {Asymmetric synthesis, Nickel catalyst, P-C coupling, P-Stereogenic phosphine, supramolecular ligands},
	issn = {0974-3626},
	doi = {10.1007/s12039-021-01978-3},
	author = {Koshti(S), Vijay S. and Chandanshive, Amol C. and Mote, Nilesh R. and Chikkali, Samir H.}
}
@article {47038,
	title = {Phosphorus ligands in hydroformylation and hydrogenation: a personal account},
	journal = {Chemical Record},
	year = {2021},
	month = {MAR},
	type = {Article; Early Access},
	abstract = {<p>Metal-catalyzed hydroformylation and hydrogenation heavily rely on ligands, among which phosphorous ligands play a pivotal role. This personal account presents a selection of three distinct classes of phosphorous ligands, namely, monodentate meta-substituted phosphinites, bis-phosphites, and P-chiral supramolecular phosphines, developed in our group. The synthesis of these ligands, isolation, characterization, and their performance in transition metal-catalyzed hydroformylation, isomerizing hydroformylation, and asymmetric hydrogenation of olefins is summarized. The state of the art development in iron-catalyzed hydroformylation of alkenes and our contributions to the field is discussed. Use of phosphines enabled iron-catalyzed hydroformylation of alkenes under mild conditions. Thus, this account demonstrates the central role of phosphorus ligands in industrially relevant transformations such as hydrogenation and hydroformylation. The seemingly matured field of ligand discovery still holds significant potential and will steer the field of homogeneous catalysis.</p>
},
	keywords = {Homogeneous catalysis, Hydroformylation, Hydrogenation, Olefins, Phosphorus ligands},
	issn = {1527-8999},
	doi = {10.1002/tcr.202100007, Early Access Date = MAR 2021},
	author = {Tewari, Tanuja and Kumar, Rohit and Chandanshive, Amol C. and Chikkali, Samir H.}
}
@article {49335,
	title = {Thermally stable P-chiral supramolecular phosphines, their self-assembly and implication in Rh-catalyzed asymmetric hydrogenation},
	journal = {Chemistry-A European Journal},
	volume = {30},
	year = {2024},
	month = {AUG },
	type = {Article},
	abstract = {<p>
	P-chiral supramolecular phosphine ligands are crucial for asymmetric transformations, but their synthesis is tedious. We report a one-step synthesis of thermally stable P-chiral supramolecular phosphines and their performance in the asymmetric hydrogenation of functionalized alkenes. A rational designing and synthesis of (R, R)-QuinoxP* ligated palladium complex (Pd-2) in excellent yield is reported. This Pd-2 catalyzed a direct P-C coupling of 2,3-dihydro-1-H-phosphindole (A1)/1,2,3,4-tetrahydrophosphindoline (A2) with 1-(3-iodophenyl)urea (B1)/2-iodo /6-hydroxy pyridine (B2) and,produced corresponding ligands L1-L3. The P-C coupling between A1 and B2 produced 6-(2,3-dihydro-1H-phosphindol-1-yl)pyridine-2(1H)-one (L2) with an excellent enantiomeric excess of up to 99 \%. L2 was found to be remarkably stable even at 150 degrees C and did not oxidize/hydrolyze for at least 24 hours in open air. Such thermal stability and an impediment to oxidation are unprecedented. L2 self-assembled and produced L2-C1 (Pt), L2-C2(Pd), and L2-C3(Rh) assemblies. The utility of the self-assembled P-chiral ligand was demonstrated in the Rh-catalyzed asymmetric hydrogenation (AH) of functionalized olefins. The L2-C3 catalyzed AH of functionalized alkenes and delivered chiral products with excellent enantioselectivity of \&gt;99 \%. A small library of 16 substrates was subjected to AH using L2-C3 to produce chiral compounds with excellent conversion and ee.</p>
},
	keywords = {asymmetric hydrogenation, Asymmetric phosphination, P-chiral phosphine, Self-assembly, Supramolecular phosphine},
	issn = {0947-6539},
	doi = {10.1002/chem.202401077},
	author = {Chandanshive, Amol C. and Gonnade, Rajesh G. and Chikkali, Samir H.}
}
