@article {47805,
	title = {Hydroformylation of olefins by metals other than rhodium},
	journal = {Journal of Organometallic Chemistry},
	volume = {960},
	year = {2022},
	month = {FEB},
	pages = {122231},
	type = {Article},
	abstract = {Metal catalyzed hydroformylation of alkenes is an atom economic transformation to construct useful aldehydes and is being industrially practiced for decades. The most commonly used metal for this transformation on an industrial scale is rhodium. However, rhodium is rare, costly, and is depleting at a skyrocketing rate. Therefore, finding a suitable alternative to rhodium for metal-catalyzed hydroformylation has been on the radar of many academic and industrial researchers. This review presents the scientific advancements reported in the hydroformylation reaction using metals other than rhodium. An overview of recent progress in palladium, iridium, ruthenium, cobalt, platinum, and iron-catalyzed hydroformylation is presented. Hydroformylation of alkenes and alkynes, using syngas as well as syngas surrogates is examined. The evaluation of the current status of non-rhodium metals in hydroformylation suggests that the field is still in a nascent stage and, except cobalt, no other metal poses a significant challenge to the dominance of rhodium. Deep mechanistic understanding of rate-limiting elementary steps in the non-rhodium metals is largely missing and thus only limited success is reported. Intense research on ligand design, mechanistic understanding, and choice of non-rhodium metal precursors may change this scenario in near future.},
	keywords = {aldehydes, alkenes, catalysis, Hydroformylation, Non-rhodium metals},
	issn = {0022-328X},
	doi = {10.1016/j.jorganchem.2021.122231},
	author = {Kumar, Rohit and Chikkali, Samir H.}
}
@article {47899,
	title = {Mechanistically guided one pot synthesis of phosphine-phosphite and its implication in asymmetric hydrogenation},
	journal = {European Journal of Organic Chemistry},
	volume = {2022},
	year = {2022},
	month = {JAN},
	pages = {e202101447},
	type = {Article},
	abstract = {<p>
	Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an 0-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72\%). When L1 was treated with [Rh], P-31 NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92\%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H-2 pressure, at room temperature. The practical relevance of Ll is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson{\textquoteright}s disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.</p>
},
	keywords = {asymmetric hydrogenation, catalysis, DOPA synthesis, One pot synthesis, Phosphine-phosphite ligand},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202101447},
	author = {Sen, Anirban and Kumar, Rohit and Pandey, Swechchha and Raj, K. Vipin and Kumar, Pawan and Vanka, Kumar and Chikkali, Samir H.}
}
