@article { ISI:000248145900007,
	title = {MgBr2-mediated ionic Diels-Alder reaction of acetals of alpha,beta-unsaturated aldehydes and ketones with 1,3-dienes},
	journal = {Synthetic Communications},
	volume = {37},
	number = {14},
	year = {2007},
	month = {JUL},
	pages = {2337-2343},
	publisher = {TAYLOR \& FRANCIS INC},
	type = {Article},
	address = {325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA},
	abstract = {<p>A facile, mild, and efficient methodology for the ionic Diels-Alder reaction of acetals of alpha,beta-unsaturated ketones and aldehydes as dienophiles with various 1,3- dienes employing MgBr2 as the Lewis acid catalyst to furnish corresponding Diels-Alder adducts at ambient temperature is described.</p>},
	keywords = {acetals, Catalysts, Diels-Alder reactions, dienes},
	issn = {0039-7911},
	doi = {10.1080/00397910701410814},
	author = {Chavan, Subhash P. and Ethiraj, Krishna S. and Dantale, Shubhada W.}
}
@article {47615,
	title = {Multi-step synthesis of miltefosine: integration of flow chemistry with continuous mechanochemistry},
	journal = {Chemistry-A European Journal},
	volume = {27},
	year = {2021},
	month = {DEC },
	pages = {17695-17699},
	type = {Article},
	abstract = {Herein we report for the first time, an advanced continuous flow synthesis of the blockbuster Leishmaniasis drug miltefosine from simple starting materials by a sequence involving four steps of chemical transformation including a continuous mechanochemical step. First three reaction steps were performed in simple tubular reactors in a telescopic mode, while in the last step the product precipitated from the 3(rd) step was used for a continuous mechanochemical synthesis of miltefosine. When compared to a typical batch protocol that takes 15 h, miltefosine was obtained in 58 \% overall yield in flow synthesis mode at the laboratory scale in a total residence time 34 min at synthesis rate of 10 g/hr, which is sufficient to treat 4800 patients per day.},
	keywords = {continuous flow, continuous mechanochemistry, miltefosine, multistep synthesis, reactive intermediates},
	issn = {0947-6539},
	doi = {10.1002/chem.202103499},
	author = {Patil, Niteen B. and Atapalkar, Ranjit S. and Chavan, Subhash P. and Kulkarni, Amol A.}
}
