@article {47659,
	title = {Stereoselective total synthesis of (+/-)-pleurospiroketals A and B},
	journal = {Journal of Organic Chemistry},
	volume = {86},
	year = {2021},
	month = {OCT },
	pages = {13572-13582},
	type = {Article},
	abstract = {A full account of our efforts toward the stereoselective total synthesis of sesquiterpenoid-derived natural products (+/-)-pleurospiroketals A and B is described. Commercially available 3-methyl-2-cyclohexenone and 2,2-dimethyloxirane were used as key building blocks, and the substrate-controlled stereoselection was exploited to access the entire stereochemistry of these natural products. Initially, a planned synthetic route involving a [6,5]-bicyclic lactone intermediate was found to be insurmountable, and the later strategy comprising OsO4-NMO-mediated dihydroxylation of 3-methyl-2-cyclohexenone, followed by Luche reduction, Eschenmoser methylenation, and Bronsted acid-induced spiroketalization steps, was ultimately identified as the reliable strategy.},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c01634},
	author = {Thorat, Sagar S. and Krishna, Gamidi Rama and Kontham, Ravindar}
}
@article {48001,
	title = {Solvent-driven mono- and bis-sulfenylation of (E)-beta-iodovinyl sulfones with thiols for flexible synthesis of 1,2-thiosulfonylalkenes and 1,2-dithioalkenes},
	journal = {Journal of Organic Chemistry},
	volume = {87},
	year = {2022},
	month = {MAR},
	pages = {3934-3951},
	type = {Article},
	abstract = {<p>
	The nature of solvent is a key factor for stereoselective mono-and bis-thiolation of (E)-beta-iodovinyl sulfones with thiols under basic conditions. A novel and unprecedented vicinal bisthiolation of (E)-beta-iodovinyl sulfones with thiols under the influence of K2CO3/DMSO at room temperature for quick assembly of (E)-1,2-dithio-1-alkenes is presented. Solvent-induced stereoselective monosulfenylation of (E)-beta-iodovinyl sulfones with thiols has also been established for the synthesis of both (E)- and (Z)-1,2-thiosulfonylethenes in MeCN and MeOH, respectively. Moreover, K2CO3-mediated desulfonylative-sulfenylation of (Z)-1,2-thiosulfonylethenes with thiols in DMSO furnished unsymmetrical (Z)-1,2-dithio-1-alkenes for the first time. The solvent-dependent versatile reactivity of (E)-beta-iodovinyl sulfones has been successfully explored to provide a set of (E)-/(Z)-1,2-dithio-1-alkenes and (E)-/(Z)-1,2-thiosulfonyl-1-alkenes in good to high yields with excellent stereoselectivities. Notably, this operationally simple process utilizes a broad substrate scope with good functional group tolerance and compatibility. The efficacy of the process has been proven for gram-scale reactions, and plausible mechanistic models are outlined on the basis of experimental results and control experiments.</p>
},
	issn = {0022-3263},
	doi = {10.1021/acs.joc.1c02444},
	author = {Reddy, Raju Jannapu and Kumari, Arram Haritha and Sharadha, Nunavath and Krishna, Gamidi Rama}
}
@article {48713,
	title = {Synthesis of N-functionalized 2,3-disubstituted benzofurans/naphthofurans from para-quinone methides and isocyanides via the [4+1] annulation pathway},
	journal = {Organic Chemistry Frontiers},
	volume = {10},
	year = {2023},
	month = {JUL},
	pages = {3746-3751},
	type = {Article},
	abstract = {<p>
	A scandium triflate catalyzed [4 + 1] cycloaddition reaction of 2-hydroxy-substituted para-quinone methides and isocyanides has been developed. This operationally simple, efficient and practical protocol provides straightforward access to a variety of N-functionalized 2,3-disubstituted benzofuran/naphthofuran derivatives with broad functional group compatibility and good scalability.</p>
},
	issn = {2052-4129},
	doi = {10.1039/d3qo00048f},
	author = {Kale, Someshwar B. and Kumar, Manish and Shinde, Dinesh R. and Krishna, Gamidi Rama and Das, Utpal}
}
