@article {46947,
	title = {Biofilm formation to inhibition: role of zinc oxide-based nanoparticles},
	journal = {Materials Science \& Engineering C-Materials for Biological Applications},
	volume = {108},
	year = {2020},
	month = {MAR},
	pages = {110319},
	type = {Review},
	abstract = {<p>Zinc oxide nanoparticles have received much attention worldwide as they possess unique properties like varied morphology, large surface area to volume ratio, potent antibacterial activity, and biocompatibility. Biofilm contains homogenous or heterogeneous microorganisms that remain enclosed in a matrix of an extracellular polymeric substance on biotic or abiotic surfaces. Bacterial biofilm formed on medical devices such as central venous catheters, urinary catheters, prosthetic joints, cardiovascular implantable devices, dental implants, contact lenses, intrauterine contraceptive devices and breast implants cause persistent infections. Such biofilm-associated infections in medical implants cause serious problems for public health and affect the function of medical implants. So, there is an urgent need for the use of an antimicrobial agent that will inhibit biofilm, including such antibiotic-resistant bacterial strains as bacteria, to develop multiple drug-resistances resulting in failure of the antibiotic{\textquoteright}s action. The antimicrobial agent used should be ideal in terms of biocompatibility, antimicrobial activity, stability at different environmental conditions, with less sensitivity to the development of resistance towards micro-organisms, safe for in vivo and in vitro use, and remain non-hazardous to the environment, etc. The first objective of the review discusses the insights into the formation of biofilm on a medical device with the current strategies to inhibit. The second purpose is to review the recent progress in ZnO- based nanostructure including composites for antibacterial and anti-biofilm activities. This will offer a new opportunity for the application of Zinc oxide-based material in the prevention of biofilm on the medical devices.</p>
},
	keywords = {antibacterial activity, Antibiofilm agent, Biocompatibility, Biofilm, Nanocomposites, ZnO nanoparticles},
	issn = {0928-4931},
	doi = {10.1016/j.msec.2019.110319},
	author = {Mahamuni-Badiger, Pranjali P. and Patil, Pooja M. and Badiger, Manohar V. and Patel, Pratikshkumar R. and Thorat-Gadgil, Bhagyashi S. and Pandit, Abhay and Bohara, Raghvendra A.}
}
@article {47622,
	title = {Manipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions},
	journal = {Polymer Engineering and Science},
	volume = {61},
	year = {2021},
	month = {OCT},
	pages = {2496-2510},
	type = {Article},
	abstract = {A hybrid of poly-l-lactic acid (PLA) and poly-epsilon-caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45 degrees with the increase in EA concentration. The rate and extent of swelling was increased 3-folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85\%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80\% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5\% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.},
	keywords = {Biocompatibility, Biomaterials, drug delivery systems, egg albumin, electrospinning, nanofibers, polyesters},
	issn = {0032-3888},
	doi = {10.1002/pen.25776},
	author = {Patel, Pratikshkumar R. and Pandey, Komal and Killi, Naresh and Gundloori, Rathna Venkata Naga}
}
