@article {46909,
	title = {Influence of fluorine substitution on the molecular conformation of 3 {\textquoteleft}-deoxy-3 {\textquoteleft}-fluoro-5-methyluriaine},
	journal = {Acta Crystallographica Section C-Structural Chemistry},
	volume = {76},
	year = {2020},
	month = {APR},
	pages = {346+},
	type = {Article},
	abstract = {<p>{Fluorine substitutions on the furanose ring of nucleosides are known to strongly influence the conformational properties of oligonucleotides. In order to assess the effect of fluorine on the conformation of 3{\textquoteright}-deoxy-3{\textquoteright}-fluoro-5-methyluridine (T-R(F)), C-10 H13FN2O5, we studied its stereochemistry in the crystalline state using X-ray crystallography. The compound crystallizes in the chiral orthorhombic space group P2(1)2(1)2(1) and contains two symmetry-independent molecules (A and B) in the asymmetric unit. The furanose ring in molecules A and B adopts conformations between envelope (E-2, 2{\textquoteright}-endo</p>
},
	keywords = {crystal structure, fluoro nucleoside, pseudorotation parameter, sugar puckering, uridine},
	issn = {2053-2296},
	doi = {10.1107/S2053229620003083},
	author = {Aher, Manisha N. and Erande, Namrata D. and Kumar, Vaijayanti A. and Fernandes, Moneesha and Gonnade, Rajesh G.}
}
@article {49010,
	title = {Implications of natural 3'-5'- linkages in the loop region of isomeric 2'-5'-linked thrombin-binding aptamer},
	journal = {Chemistryselect},
	volume = {9},
	year = {2024},
	month = {APR },
	type = {Article},
	abstract = {<p>
	The backbone modification of the thrombin-binding aptamer (TBA) in the TT and TGT loop regions by isomeric 2 {\textquoteleft}-5 {\textquoteleft}-linkages was found to impose additive destabilizing effects on the thermal stability of the G-quadruplex structure. In contrast, the thermal stability of isomeric 2 {\textquoteleft}-5 {\textquoteleft}-linked TBA, i. e., isoTBA, was significantly improved by isomeric 3 {\textquoteleft}-5 {\textquoteleft}-phosphodiester linkages. The isoTBA, when modified with 3 {\textquoteleft}-5 {\textquoteleft}-linkages in both lateral TT loops (isoTBA202), exhibited higher thermal stability and enzymatic stability in comparison to other oligomers in the present study, and TBA202 showed higher antithrombin activity than other loop-modified TBA oligomers.</p>
},
	keywords = {2 {\textquoteleft}-5 {\textquoteleft}-linked-linked DNA, DNA-isoDNA chimera, isoDNA, loop-modification, thrombin-binding aptamer},
	issn = {2365-6549},
	doi = {10.1002/slct.202304254},
	author = {Aher, Manisha and Kumar, Vaijayanti A. and Fernandes, Moneesha}
}
