@article {49349,
	title = {2,3-Difunctionalization of quinones: a gold-catalyzed cascade approach for trifluoromethyl-amination or sulfoximination},
	journal = {Chemical Communications},
	volume = {60},
	year = {2024},
	month = {AUG },
	pages = {9598-9601},
	type = {Article},
	abstract = {<p>
	A one-pot domino protocol employing gold(i) catalysis has been developed for the cascade trifluoromethyl-amination/sulfoximination of quinones. Togni I serves as the trifluoromethyl installing precursor, while amine or sulfoximine serves as the aminating source. Preliminary investigations suggest a mutual activation of Togni I and the amine precursor, facilitating the facile difunctionalization of quinones with excellent regioselectivity. Extensive substrate scope exploration demonstrates moderate to good yields of difunctionalized products. Application to the natural product Juglone highlights its potential for late-stage modifications in medicinal chemistry and drug discovery. A one-pot domino protocol employing gold(i) catalysis has been developed for the cascade trifluoromethyl-amination/sulfoximination of quinones.</p>
},
	issn = {1359-7345},
	doi = {10.1039/d4cc01891e},
	author = {Sharma, Alpa and Govande, Vijaya and Mahajan, Shivangani and Sawant, Sanghapal D.}
}
@article {49359,
	title = {C-H functionalization of imidazo[1,5-a]pyridines: a metal-free approach for methylene insertion to access C(sp2)-C(sp3)-H-C(sp2) bond formation},
	journal = {ACS Omega},
	volume = {9},
	year = {2024},
	month = {DEC },
	pages = {49071-49080},
	type = {Article},
	abstract = {<p>
	Formaldehyde has been used as a solvent and a source of carbon to insert a methylene group for bridging two imidazo[1,5-a]pyridine molecules without using any metal catalysis. This strategy has been extended on other alkyl-, aryl-, and heteroaryl aldehydes as well. This C(sp2)-C(sp3)-H-C(sp2) bond forming reaction proceeds via C(sp2)H functionalization of imidazo[1,5-a]pyridine and was applied on a wide range of substrates offering moderate to good yields of methylene-bridged/inserted bis-imidazo[1,5-a]pyridines. Most importantly, as an application, the bis-heteroarene product has been demonstrated as a ligand. The ligand-like behavior of bis-imidazo[1,5-a]pyridines has been demonstrated as an extension of current methodology. This reaction works well at the gram scale level.</p>
},
	issn = {2470-1343},
	doi = {10.1021/acsomega.4c03823},
	author = {Mahajan, Shivangani and Sawant, Sanghapal D.}
}
