@article {49320,
	title = {1,6-Conjugate addition of in situ generated aryldiazenes to p-quinone methides},
	journal = {Organic \& Biomolecular Chemistry},
	volume = {22},
	year = {2024},
	month = {JUL},
	pages = {5636-5645},
	type = {Article},
	abstract = {<p>
	Herein we report a transition-metal free, base-mediated 1,6-conjugate addition of aryldiazenes to para-quinone methides (p-QMs). Arylhydrazines were used for the in situ generation of aryldiazenes using a base-mediated protocol in the presence of air as the oxidant. The 1,6-conjugate addition of aryldiazenes to para-quinone methides via a radical mechanism is followed by an oxidative rearrangement to furnish the desired product, arylhydrazones. Interestingly, our synthetic protocol results in the formation of an aryldiazene radical, which undergoes 1,6-conjugate addition with p-QMs to furnish the arylhydrazones.</p>
},
	issn = {1477-0520},
	doi = {10.1039/d4ob00618f},
	author = {Mamale, Ajay G. and Paul, Sayantan and Gonnade, Rajesh G. and Bhattacharya, Asish K.}
}
@article {49300,
	title = {Methanesulfonic acid-catalyzed friedel-crafts alkylation: towards sustainable synthesis of arylalkanes from donor-acceptor cyclopropane ketones},
	journal = {Asian Journal of Organic Chemistry},
	volume = {13},
	year = {2024},
	month = {JUL},
	type = {Article},
	abstract = {<p>
	We present herein Br \&amp; oslash;nsted acid-catalyzed Friedel-Crafts alkylation of phenols with Donor-Acceptor cyclopropane ketones. The presence of the 1,4-diphenyl butan-1-one and 1,3-diphenyl propane-1-one motifs in various naturally occurring biologically significant molecules inspired us to pursue the direct synthesis of these structural frameworks. Utilizing methanesulfonic acid (MeSO3H) as a catalyst, we achieved a more environmentally friendly and high-yielding synthesis, owing to its cost-effectiveness, biodegradability, transition-metal and additives free conditions. Furthermore, we have successfully extended our developed methodology to thiophenols, resulting in the production of sulfur-based butan-1-one derivatives in good yields. The presence of 1,4-diphenyl butan-1-one and 1,3-diphenyl propane-1-one motifs in various naturally occurring biologically significant molecules prompted us to develop a Br \&amp; oslash;nsted acid-catalyzed Friedel-Crafts alkylation of phenols with Donor-Acceptor cyclopropane. image</p>
},
	keywords = {donor-acceptor cyclopropane, Friedel-Crafts alkylation, methanesulfonic acid, Phenols, thiophenol},
	issn = {2193-5807},
	doi = {10.1002/ajoc.202400116},
	author = {Goswami, Lakshmi and Paul, Sayantan and Mamale, Ajay G. and Gonnade, Rajesh G. and Bhattacharya, Asish K.}
}
