@article {47407, title = {Interrupting the [Au]-catalyzed nitroalkyne cycloisomerization: trapping the putative alpha-oxo gold carbene with benzo[c]isoxazole}, journal = {Organic Letters}, volume = {23}, year = {2021}, month = {APR }, pages = {2632-2637}, type = {Article}, abstract = {

The [Au]-catalyzed nitroalkyne cycloisomerization of 2-alkynylnitrobenzenes leading to anthranils has been interrupted by possible trapping of the postulated intermediate alpha-oxo gold carbene with an external nucleophile such as benzo[c]isoxazole (anthranil). At the outset, this provides a simple synthesis of highly functionalized 3-acyl-(2-formylphenyl)-2H-indazoles with the sequential C-O, C-N, and N-N bond formations. This provides indirect support for the existence of alpha-oxo gold carbenes in the [Au]-catalyzed internal redox processes of nitroalkynes.

}, issn = {1523-7060}, doi = {10.1021/acs.orglett.1c00539}, author = {Dhote, Pawan S. and Ramana, V, Chepuri} }