@article {45947, title = {Chirality induction and chiron approaches to enantioselective total synthesis of alpha-lipoic acid}, journal = {Tetrahedron}, volume = {71}, year = {2015}, month = {JUN }, pages = {4213-4218}, type = {Article}, abstract = {

An efficient, short and convenient asymmetric synthesis of (R)-(+)-lipoic acid in seven steps from chiral hydroxy aldehyde with 32.5\% overall yield is described. Synthesis of S and R enantiomers of a-lipoic acid from cis-1,4-butene diol derived chiral lactone is reported with 34 \% overall yield. The present synthesis involves use of simple reaction conditions making it a convenient synthesis. (C) 2015 Elsevier Ltd. All rights reserved.

}, keywords = {Chiral pool, Chirality induction, enantioselective, Lipoic acid, sharpless asymmetric dihydroxylation}, issn = {0040-4020}, doi = {10.1016/j.tet.2015.04.090}, author = {Chavan, Subhash P. and Pawar, Kailash P. and Praveen, Ch and Patil, Niteen B.} }