@article {45358, title = {Employing arynes for the generation of aryl anion equivalents and subsequent reaction with aldehydes}, journal = {Journal of Organic Chemistry}, volume = {83}, year = {2018}, month = {SEP}, pages = {11333-11340}, type = {Article}, abstract = {

Arynes are highly reactive intermediates, which are utilized for the electrophilic arylation of various X-H bonds (X = O, N, S etc.). Herein, a new synthetic strategy is demonstrated, where arynes are converted into aryl anion equivalents by treatment with phosphines and a base. The addition of phosphines to arynes form the phosphonium salts, which in the presence of a carbonate base generates the aryl anion equivalent. Subsequent addition of the aryl anions with aldehydes afforded the secondary alcohols.

}, doi = {10.1021/acs.joc.8b01549}, author = {Gaykar, Rahul N. and Bhunia, Anup and Biju, Akkattu T.} }