@article { ISI:000266693600010, title = {Formal synthesis of (-) anisomycin via organocatalysis}, journal = {Arkivoc}, year = {2009}, month = {JAN}, pages = {88-94}, publisher = {ARKAT USA INC}, address = {C/O ALAN R KATRITZKY, UNIV FLORIDA, DEPT CHEMISTRY, PO BOX 117200, GAINESVILLE, FL 32611 USA}, abstract = {

An efficient formal synthesis of (-) anisomycin (1), a potent antibiotic agent, has been achieved in good yields and excellent diastereoselectivity. The key steps are proline-catalyzed sequential alpha-amination or alpha-aminoxylation of aldehyde 2 followed by tandem Horner-Wadsworth-Emmons olefination.

}, keywords = {alpha-Amination, alpha-aminoxylation, anisomycin, olefination, Proline}, issn = {1424-6376}, author = {Chouthaiwale, Pandurang V. and Kotkar, Shriram P. and Sudalai, Arumugam} }