@article { ISI:000326121700015, title = {Asymmetric N-heterocyclic carbene (NHC)-catalyzed annulation of modified enals with enolizable aldehydes}, journal = {Organic Letters}, volume = {15}, number = {20}, year = {2013}, month = {OCT}, pages = {5202-5205}, publisher = {AMER CHEMICAL SOC}, address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA}, abstract = {

N-Heterocyclic carbene (NHC)-catalyzed highly enantioselective lactonization of modified enals with enolizable aldehydes, proceeding via the alpha,beta-unsaturated acylazolium intermediates, is reported. The reaction results in the asymmetric synthesis of synthetically important 4,5-disubstituted dihydropyranones.

}, issn = {1523-7060}, doi = {10.1021/ol4026155}, author = {Yetra, Santhivardhana Reddy and Kaicharla, Trinadh and Kunte, Sunita S. and Gonnade, Rajesh G. and Biju, Akkattu T.} }